Issue 84, 2016
From the journal:

Chemical Communications

A dual-functional supramolecular hydrogel based on a spiropyran–galactose conjugate for target-mediated and light-controlled delivery of microRNA into cells†

Xiao Xiao,a   Jing Hu,a   Xingxing Wang,a   Lei Huang,a   Yingjie Chen,a   Wei Wang,a   Jinbo Li*a  and  Yan Zhang*a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: njuzy@nju.edu.cn, jinboli@nju.edu.cn

Abstract

A supramolecular hydrogel formed by spiropyran conjugated galactose was developed for light-controlled release of miR-122 and target-mediated delivery of the miRNA into HepG2 cells cultured on top of the gel.

Graphical abstract: A dual-functional supramolecular hydrogel based on a spiropyran–galactose conjugate for target-mediated and light-controlled delivery of microRNA into cells

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Article information

DOI
https://doi.org/10.1039/C6CC07386G
Article type
Communication
Submitted
10 Sep 2016
Accepted
29 Sep 2016
First published
29 Sep 2016

Chem. Commun., 2016,52, 12517-12520

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A dual-functional supramolecular hydrogel based on a spiropyran–galactose conjugate for target-mediated and light-controlled delivery of microRNA into cells

X. Xiao, J. Hu, X. Wang, L. Huang, Y. Chen, W. Wang, J. Li and Y. Zhang, Chem. Commun., 2016, 52, 12517 DOI: 10.1039/C6CC07386G

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