Issue 98, 2016
From the journal:

Chemical Communications

Self-assembling nanowires of an amphiphilic camptothecin prodrug derived from homologous derivative conjugation†

Dongxuan He,‡abc   Wei Zhang,‡bd   Hongzhang Deng,ac   Shuaidong Huo,bd   Yi-Feng Wang,bd   Ningqiang Gong,bd   Liandong Deng,ac   Xing-Jie Liang*bd  and  Anjie Dong*ac  

* Corresponding authors

a Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China
E-mail: ajdong@tju.edu.cn

b Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience; and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, No. 11, First North Road Zhongguangcun, Beijing, P. R. China
E-mail: liangxj@nanoctr.cn

c Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China

d University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

A novel amphiphilic camptothecin prodrug, CPT-ss-Ir, consisting of CPT, Ir and a disulfide bond linker, was synthesized, and it could self-assemble into nanowires in aqueous solution. Upon intracellular triggering, active CPT and Ir species were released to exert a considerable anticancer effect.

Graphical abstract: Self-assembling nanowires of an amphiphilic camptothecin prodrug derived from homologous derivative conjugation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC07595A
Article type
Communication
Submitted
18 Sep 2016
Accepted
11 Nov 2016
First published
11 Nov 2016

Chem. Commun., 2016,52, 14145-14148

Permissions

Request permissions

Self-assembling nanowires of an amphiphilic camptothecin prodrug derived from homologous derivative conjugation

D. He, W. Zhang, H. Deng, S. Huo, Y. Wang, N. Gong, L. Deng, X. Liang and A. Dong, Chem. Commun., 2016, 52, 14145 DOI: 10.1039/C6CC07595A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements