Issue 98, 2016
From the journal:

Chemical Communications

Rhodium-catalyzed C–H activation of 3-(indolin-1-yl)-3-oxopropanenitriles with diazo compounds and tandem cyclization leading to hydrogenated azepino[3,2,1-hi]indoles†

Tao Zhou,a   Bin Lia  and  Baiquan Wang*abc  

* Corresponding authors

a State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China
E-mail: bqwang@nankai.edu.cn
Fax: +86 (22) 23504781
Tel: +86 (22) 23504781

b Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China

c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

Abstract

Rh(III)-Catalyzed C–H activation of 3-(indolin-1-yl)-3-oxopropanenitriles with diazo compounds and cyclization leading to seven-membered ring scaffolds has been developed. These reactions involving tandem C–H activation, cyclization, and condensation steps proceed efficiently and display a broad scope of substrates.

Graphical abstract: Rhodium-catalyzed C–H activation of 3-(indolin-1-yl)-3-oxopropanenitriles with diazo compounds and tandem cyclization leading to hydrogenated azepino[3,2,1-hi]indoles

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Article information

DOI
https://doi.org/10.1039/C6CC07758G
Article type
Communication
Submitted
24 Sep 2016
Accepted
10 Nov 2016
First published
10 Nov 2016

Chem. Commun., 2016,52, 14117-14120

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Rhodium-catalyzed C–H activation of 3-(indolin-1-yl)-3-oxopropanenitriles with diazo compounds and tandem cyclization leading to hydrogenated azepino[3,2,1-hi]indoles

T. Zhou, B. Li and B. Wang, Chem. Commun., 2016, 52, 14117 DOI: 10.1039/C6CC07758G

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