Trimethyllysine hydroxylase (TMLH) is a non-haem Fe(II) and 2-oxoglutarate dependent oxygenase that catalyses the C-3 hydroxylation of an unactivated C–H bond in L-trimethyllysine in the first step of carnitine biosynthesis. The examination of trimethyllysine analogues as substrates for human TMLH reveals that the enzyme does hydroxylate substrates other than natural L-trimethyllysine.
A. H. K. Al Temimi, B. J. G. E. Pieters, Y. V. Reddy, P. B. White and J. Mecinović, Chem. Commun., 2016, 52, 12849 DOI: 10.1039/C6CC07845A
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