Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)–H bonds

Abstract

An efficient and convenient method has been developed to achieve direct silylation of unactivated remote primary or secondary C(sp³)–H bonds to form C–Si bonds with hexamethyldisilane (HMDS). This method highlights the emerging strategy to transform unactivated methyl or methylene into versatile functional groups in organic synthesis and provides a new method to construct functionalized C–Si bonds for synthetic chemistry.