Issue 100, 2016
From the journal:

Chemical Communications

A three-dimensional graphene oxide supramolecular hydrogel for infrared light-responsive cascade release of two anticancer drugs†

Wei Ha,a   Xiao-Bo Zhao,a   Kan Jiang,a   Yang Kang,b   Juan Chen,a   Bang-Jing Li*b  and  Yan-Ping Shi*a  

* Corresponding authors

a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
E-mail: shiyp@licp.cas.cn

b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China
E-mail: libj@cib.ac.cn

Abstract

A three dimensional supramolecular hydrogel consisting of prodrug-modified graphene oxide and α-cyclodextrin was developed. This hydrogel with a well-ordered interior microstructure integrated hydrophobic and hydrophilic anticancer drugs into a single multifunctional platform, and underwent a gel–sol transition leading to cascade release of two drugs in an on-demand fashion upon NIR light irradiation.

Graphical abstract: A three-dimensional graphene oxide supramolecular hydrogel for infrared light-responsive cascade release of two anticancer drugs

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Article information

DOI
https://doi.org/10.1039/C6CC08123A
Article type
Communication
Submitted
08 Oct 2016
Accepted
21 Nov 2016
First published
21 Nov 2016

Chem. Commun., 2016,52, 14384-14387

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A three-dimensional graphene oxide supramolecular hydrogel for infrared light-responsive cascade release of two anticancer drugs

W. Ha, X. Zhao, K. Jiang, Y. Kang, J. Chen, B. Li and Y. Shi, Chem. Commun., 2016, 52, 14384 DOI: 10.1039/C6CC08123A

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