Issue 94, 2016
From the journal:

Chemical Communications

Oxidative trifluoromethylation and fluoroolefination of unactivated olefins†

Ye-bin Wu,a   Guo-ping Lu,a   Tao Yuan,a   Zhu-bing Xu,a   Li Wanb  and  Chun Cai*ac  

* Corresponding authors

a Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu, People's Republic of China
E-mail: c.cai@njust.edu.cn

b Biotechnology and Pharmaceutical Engineering College, Nanjing Tech University, Nanjing 211816, People's Republic of China

c Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 20032, People's Republic of China

Abstract

Fluorine-containing organic compounds are gaining increasing importance in medicinal chemistry. Described herein is a mild and efficient method for the radical addition of olefins with TMSCF3 and TMSCF2R (R = COOEt or CF3) to deliver various α-trifluoromethylated ketones and α-fluoroolefinated ketones.

Graphical abstract: Oxidative trifluoromethylation and fluoroolefination of unactivated olefins

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Article information

DOI
https://doi.org/10.1039/C6CC08178A
Article type
Communication
Submitted
11 Oct 2016
Accepted
26 Oct 2016
First published
26 Oct 2016

Chem. Commun., 2016,52, 13668-13670

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Oxidative trifluoromethylation and fluoroolefination of unactivated olefins

Y. Wu, G. Lu, T. Yuan, Z. Xu, L. Wan and C. Cai, Chem. Commun., 2016, 52, 13668 DOI: 10.1039/C6CC08178A

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