A first free-radical triggered site-specific cross dehydrogenative coupling reaction of heterocycles with simple nitriles is developed. It allows efficient and facile access to various C-2 cyanoalkylated furans, thiophenes, indoles, and pyrroles. The extremely high selectivities in this case indicate that functionalization of an inert C–H bond could be well-controlled by radical initiation.
Z. Liu and Z. Li, Chem. Commun., 2016, 52, 14278 DOI: 10.1039/C6CC08213K
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