Issue 99, 2016

Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis

Abstract

Aj_EasH is a non-heme iron- and α-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 Å resolution) reported here provides insight into the mechanism of this unusual and complex reaction.

Graphical abstract: Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
19 Oct 2016
Accepted
22 Nov 2016
First published
22 Nov 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 14306-14309

Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis

D. Jakubczyk, L. Caputi, C. E. M. Stevenson, D. M. Lawson and S. E. O'Connor, Chem. Commun., 2016, 52, 14306 DOI: 10.1039/C6CC08438A

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