Issue 6, 2016

Catalytic asymmetric dearomatization (CADA) reactions of phenol and aniline derivatives

Abstract

Phenols are widely used as starting materials in both industrial and academic society. Dearomatization reactions of phenols provide an efficient way to construct highly functionalized cyclohexadienones. The main challenge to make them asymmetric by catalytic methods is to control the selectivity while overcoming the loss of aromaticity. In this tutorial review, an up to date summary of recent progress in CADA reactions of phenol and aniline derivatives is presented.

Graphical abstract: Catalytic asymmetric dearomatization (CADA) reactions of phenol and aniline derivatives

Article information

Article type
Tutorial Review
Submitted
29 Apr 2015
First published
22 Jan 2016
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2016,45, 1570-1580

Catalytic asymmetric dearomatization (CADA) reactions of phenol and aniline derivatives

W. Wu, L. Zhang and S. You, Chem. Soc. Rev., 2016, 45, 1570 DOI: 10.1039/C5CS00356C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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