Issue 6, 2016

Nickel-catalyzed direct alkynylation of C(sp2)–H bonds of amides: an “inverse Sonogashira strategy” to ortho-alkynylbenzoic acids

Abstract

Nickel-catalyzed direct alkynylation of C(sp2)–H bonds of amides using commercially available, inexpensive 8-aminoquinoline as a removable bidentate directing group is described. The present ortho-alkynylation has a broad substrate scope, functional group tolerance and high regiocontrol, and can be scaled up. The efficiency and selectivity of this strategy provide sustainable routes to a diverse array of ortho-alkynylbenzoic acids under Ni(II)-catalyzed conditions.

Graphical abstract: Nickel-catalyzed direct alkynylation of C(sp2)–H bonds of amides: an “inverse Sonogashira strategy” to ortho-alkynylbenzoic acids

Supplementary files

Article information

Article type
Paper
Submitted
08 Aug 2015
Accepted
09 Oct 2015
First published
23 Oct 2015

Catal. Sci. Technol., 2016,6, 1946-1951

Author version available

Nickel-catalyzed direct alkynylation of C(sp2)–H bonds of amides: an “inverse Sonogashira strategy” to ortho-alkynylbenzoic acids

V. G. Landge, C. H. Shewale, G. Jaiswal, M. K. Sahoo, S. P. Midya and E. Balaraman, Catal. Sci. Technol., 2016, 6, 1946 DOI: 10.1039/C5CY01299F

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