Zinc(II)–NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway. The strategy represents a general procedure to convert non-selective or COX-1 selective NSAIDs to selective COX-2 inhibitors.
T. R. Lakshman, J. Deb and T. K. Paine, Dalton Trans., 2016, 45, 14053 DOI: 10.1039/C6DT00838K
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