Issue 1, 2016

Modulation of hepatocarcinogenesis in N-methyl-N-nitrosourea treated Balb/c mice by mushroom extracts

Abstract

The hepatoprotective potential of edible mushrooms from Mauritius, namely Pleurotus sajor-caju and Agaricus bisporus was evaluated using an N-methyl-N-nitrosourea (MNU)-induced hepatocarcinogenesis Balb/c mice model. Mushroom extracts restored normal weight in MNU treated mice over a 3 month supplementation period. Blood parameter analyses indicated a clear modulation of hemoglobin concentration, leukocyte, platelet, lymphocyte, neutrophil, monocyte and eosinophil counts in MNU-induced mice (p < 0.05). Mushroom extract supplementation effectively reduced oxidative damage in MNU-primed mice, which was marked by a significant decrease in the extent of lipid peroxidation (p < 0.05) and a concomitant increase in the enzymatic antioxidant levels, primarily catalase, superoxide dismutase, glutathione reductase and peroxidase, and FRAP values (p < 0.05). DNA protective effects of the extracts were confirmed by Raman spectroscopy, where, the MNU–DNA interaction, as evidenced by an intense peak at 1254 cm−1, was normalized. The findings demonstrate hepatoprotective, immunomodulatory and anti-carcinogenic effects and suggest the use of mushrooms as potential dietary prophylactics in cancer chemoprevention.

Graphical abstract: Modulation of hepatocarcinogenesis in N-methyl-N-nitrosourea treated Balb/c mice by mushroom extracts

Article information

Article type
Paper
Submitted
16 Jul 2015
Accepted
25 Oct 2015
First published
03 Nov 2015

Food Funct., 2016,7, 594-609

Author version available

Modulation of hepatocarcinogenesis in N-methyl-N-nitrosourea treated Balb/c mice by mushroom extracts

S. Ramsaha, V. S. Neergheen-Bhujun, S. Verma, A. Kumar, R. K. Bharty, A. K. Chaudhary, P. Sharma, R. K. Singh, P. Huzar Futty Beejan, K. Kyung-Sun and T. Bahorun, Food Funct., 2016, 7, 594 DOI: 10.1039/C5FO00870K

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