Issue 6, 2016

d-Xylonic acid: a solvent and an effective biocatalyst for a three-component reaction

Abstract

A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones and their derivatives from aldehydes, β-dicarbonyl compounds and urea or thiourea using D-xylonic acid both as a green solvent and an effective catalyst is described. Taking the environment and economy into account, the work presented here has the merits of environmental friendliness, easy operation, simple work-up, excellent yields and the avoidance of organic solvents and inexpensive catalysts. In addition, the good properties of D-xylonic acid have also been validated by the synthesis of 5-phenyl-1(4-methoxyphenyl)-3[(4-methoxyphenyl)-amino]-1H-pyrrol-2(5H)-one and 12-phenyl-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one. The synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR and melting point.

Graphical abstract: d-Xylonic acid: a solvent and an effective biocatalyst for a three-component reaction

Supplementary files

Article information

Article type
Paper
Submitted
27 Jul 2015
Accepted
30 Oct 2015
First published
03 Nov 2015

Green Chem., 2016,18, 1738-1750

Author version available

D-Xylonic acid: a solvent and an effective biocatalyst for a three-component reaction

J. Ma, L. Zhong, X. Peng and R. Sun, Green Chem., 2016, 18, 1738 DOI: 10.1039/C5GC01727K

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