Carboxylative cyclization of substituted propenyl ketones using CO2: transition-metal-free synthesis of α-pyrones

Abstract

Carbon dioxide is a green carboxylative reagent due to its non-toxic and renewable properties. Described herein is a carboxylative cyclization of substituted 1-propenyl ketones via γ-carboxylation using CO₂, which provides an efficient, transition-metal-free and straightforward access to important α-pyrone compounds from easily available substrates and CO₂.