Luminescent, cell-based assays capable of monitoring the aggregation potential of the disease-relevant proteins known as amylin (type 2 diabetes) and huntingtin (Huntington's disease) are presented. These sensitive platforms report on the influence of mutations as well as small molecules on protein solubility.
J. Zhao, Q. Vu and C. I. Stains, Mol. BioSyst., 2016, 12, 2984 DOI: 10.1039/C6MB00454G
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