Fabrication of fluorescent nanoparticles based on AIE luminogens (AIE dots) and their applications in bioimaging

Sijie Chen; Hong Wang; Yuning Hong; Ben Zhong Tang

doi:10.1039/C6MH00060F

Fabrication of fluorescent nanoparticles based on AIE luminogens (AIE dots) and their applications in bioimaging

Sijie Chen,^abc Hong Wang,^a Yuning Hong^b and Ben Zhong Tang*^ade

* Corresponding authors

^a Division of Biomedical Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Division of Life Science, Institute of Molecular Functional Materials and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

^b School of Chemistry, The University of Melbourne, Parkville, VIC 3000, Australia

^c Research Division of Biomaterials and Regenerative Medicine, Department of Medical Biochemistry and Biophysics, Karolinsika Institute, SE 17177 Stockholm, Sweden

^d HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park Nanshan, Shenzhen 518057, China

^e Guangdong Innovative Research Team, SCUT-HKUST Joint Research Laboratory, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology (SCUT), Guangzhou 510640, China

Abstract

Fluorescent nanoparticles (NPs) represent a new group of contrast agents for bioimaging. One of the challenging problems in this area is to fabricate fluorescent NPs with improved brightness, photostability and biocompatibility. The recently discovered aggregation-induced emission (AIE) luminogens, which exhibit enhanced emission upon aggregate formation, may circumvent these problems. Incorporating AIE fluorophores into the NP platform results in AIE dots with greatly enhanced fluorescence efficiency and superior photostability. In this review, we will summarize our effort in the last five years on the fabrication of AIE dots and their applications in bioimaging.

Article information

https://doi.org/10.1039/C6MH00060F

Article type

Review Article

Submitted

05 Mar 2016

Accepted

12 Apr 2016

First published

12 Apr 2016

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Mater. Horiz., 2016,3, 283-293

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Fabrication of fluorescent nanoparticles based on AIE luminogens (AIE dots) and their applications in bioimaging

S. Chen, H. Wang, Y. Hong and B. Z. Tang, Mater. Horiz., 2016, 3, 283 DOI: 10.1039/C6MH00060F

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Fabrication of fluorescent nanoparticles based on AIE luminogens (AIE dots) and their applications in bioimaging

Abstract

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Fabrication of fluorescent nanoparticles based on AIE luminogens (AIE dots) and their applications in bioimaging

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