Core–shell type ‘nanoghosts’ were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.
S. Krishnamurthy, M. K. Gnanasammandhan, C. Xie, K. Huang, M. Y. Cui and J. M. Chan, Nanoscale, 2016, 8, 6981 DOI: 10.1039/C5NR07588B
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