Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

E. I. Alarcon; B. Vulesevic; A. Argawal; A. Ross; P. Bejjani; J. Podrebarac; R. Ravichandran; J. Phopase; E. J. Suuronen; M. Griffith

doi:10.1039/C6NR01339B

Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine†

E. I. Alarcon,*^a B. Vulesevic,^a A. Argawal,^a A. Ross,^a P. Bejjani,^a J. Podrebarac,^a R. Ravichandran,^b J. Phopase,^b E. J. Suuronen^a and M. Griffith*^c

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* Corresponding authors

^a Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Canada

^b Department of Physics, Chemistry and Biology, Linköping University, SE 581 83 Linköping, Sweden

^c Integrative Regenerative Medicine Centre, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
E-mail: ealarcon@ottawaheart.ca, May.Griffith@liu.se

Abstract

Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to pre-stabilize and incorporate AgNPs with different colours into collagen matrices for fabrication of corneal implants and lenses, and assessed their in vitro and in vivo activity.

Nanoscale

Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine†

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Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

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