Issue 26, 2016

Polypyrrole-encapsulated iron tungstate nanocomposites: a versatile platform for multimodal tumor imaging and photothermal therapy

Abstract

A versatile nanoplatform of FeWO4@Polypyrrole (PPy) core/shell nanocomposites, which was facilely fabricated by first hydrothermal synthesis of FeWO4 nanoparticles and subsequent surface-coating of polypyrrole shell, was developed as an effective nanotheranostic agent of cancer. The as-prepared nanocomposites demonstrated excellent dispersion in saline, long-term colloidal storage, outstanding photo-stability and high photothermal efficiency in solution. In particular, FeWO4@PPy exhibited efficient performance for hyperthermia-killing of cancer cells under the irradiation of an 808 nm laser, accompanied with multimodal contrast capabilities for magnetic resonance imaging, X-ray computed tomography and infrared thermal imaging in vitro and in vivo. Furthermore, the nanocomposites presented impactful tumor growth inhibition and good biocompability in animal experiments. Blood circulation and biodistribution of the nanocomposites were also investigated to understand their in vivo behaviours. Our results verified the platform of FeWO4@PPy nanocomposites as a promising photothermal agent for imaging-guided cancer theranostics.

Graphical abstract: Polypyrrole-encapsulated iron tungstate nanocomposites: a versatile platform for multimodal tumor imaging and photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
24 Apr 2016
Accepted
23 May 2016
First published
25 May 2016

Nanoscale, 2016,8, 12917-12928

Polypyrrole-encapsulated iron tungstate nanocomposites: a versatile platform for multimodal tumor imaging and photothermal therapy

Z. Xiao, C. Peng, X. Jiang, Y. Peng, X. Huang, G. Guan, W. Zhang, X. Liu, Z. Qin and J. Hu, Nanoscale, 2016, 8, 12917 DOI: 10.1039/C6NR03336A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements