BH3 domain mimetics based on the small protein scyllatoxin (ScTx) were designed to target the anti-apoptotic protein Bcl2 in vitro. Intrinsically disordered ScTx variants were found to bind Bcl2 with nanomolar affinity, indicating that an induced fit binding mechanism is required for favorable BH3 : Bcl2 interaction.
M. M. Harris, Z. Coon, N. Alqaeisoom, B. Swords and J. M. Holub, Org. Biomol. Chem., 2016, 14, 440 DOI: 10.1039/C5OB02080H
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