Issue 1, 2016
From the journal:

Organic & Biomolecular Chemistry

Efficient, versatile and practical palladium-catalyzed highly regioselective ortho-halogenation of azoxybenzenes†

Meng Sun,*a   Xiangxiang Chen,a   Liang Zhang,a   Wei Sun,a   Zhe Wang,a   Peiyu Guo,a   Ya-Min Lib  and  Xiao-Juan Yanga  

* Corresponding authors

a Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710127, P. R. China
E-mail: sunmeng@nwu.edu.cn

b Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming Nanlu, Kunming 650500, P. R. China

Abstract

A highly efficient and practical strategy for regio-selective ortho-halogenation (I, Br, Cl) of azoxybenzenes with NXS in the presence of palladium catalysts has been developed in good to excellent yields. The reaction proceeds smoothly and can tolerate a variety of functional groups. Moreover, this chemistry can be applied to substrates in at least a gram scale.

Graphical abstract: Efficient, versatile and practical palladium-catalyzed highly regioselective ortho-halogenation of azoxybenzenes

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Article information

DOI
https://doi.org/10.1039/C5OB02153G
Article type
Paper
Submitted
19 Oct 2015
Accepted
04 Nov 2015
First published
06 Nov 2015

Org. Biomol. Chem., 2016,14, 323-329

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Efficient, versatile and practical palladium-catalyzed highly regioselective ortho-halogenation of azoxybenzenes

M. Sun, X. Chen, L. Zhang, W. Sun, Z. Wang, P. Guo, Y. Li and X. Yang, Org. Biomol. Chem., 2016, 14, 323 DOI: 10.1039/C5OB02153G

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