A three-component reagent system for rapid and mild removal of O-, N- and S-trityl protecting groups

Abstract

A new reagent system consisting of a Lewis acid such as BF₃·Et₂O or Cu(OTf)₂, the mild protic acid hexafluoroisopropanol and the reducing quenching agent triethylsilane was elaborated for O-, N- and S-detritylation of nucleoside, carbohydrate and amino acid derivatives. The method is compatible with acetyl, silyl, acetal and Fmoc groups.