Issue 27, 2016
From the journal:

Organic & Biomolecular Chemistry

N-Heterocyclic carbene-triggered transition-metal-free synthesis of 2,3-disubstituted benzofuran derivatives†

Yuanwei Xie,‡a   Chenxia Yu,‡a   Yonglei Que,a   Tuanjie Li,a   Yuhong Wang,a   Yinan Lu,a   Wenjing Wang,a   Shide Shenb  and  Changsheng Yao*a  

* Corresponding authors

a Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China
E-mail: csyao@jsnu.edu.cn
Fax: (+86)516-83500365

b Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu, China

Abstract

An NHC-triggered, transition-metal-free strategy for the efficient synthesis of 2,3-disubstituted benzofuran derivatives in moderate to excellent yields from aryl or alkyl aldehydes and o-quinone methides has been developed. This method features mild reaction conditions, operational simplicity, broad substrate scope and convergent assembly.

Graphical abstract: N-Heterocyclic carbene-triggered transition-metal-free synthesis of 2,3-disubstituted benzofuran derivatives

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Article information

DOI
https://doi.org/10.1039/C6OB00363J
Article type
Paper
Submitted
15 Feb 2016
Accepted
29 May 2016
First published
31 May 2016

Org. Biomol. Chem., 2016,14, 6463-6469

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N-Heterocyclic carbene-triggered transition-metal-free synthesis of 2,3-disubstituted benzofuran derivatives

Y. Xie, C. Yu, Y. Que, T. Li, Y. Wang, Y. Lu, W. Wang, S. Shen and C. Yao, Org. Biomol. Chem., 2016, 14, 6463 DOI: 10.1039/C6OB00363J

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