Issue 16, 2016
From the journal:

Organic & Biomolecular Chemistry

Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring†

Renata Kasprzyk,abc   Joanna Kowalska, ORCID logo *a   Zbigniew Wieczorek,d   Mariusz Szabelski,d   Ryszard Stolarskia  and  Jacek Jemielity ORCID logo *b  

* Corresponding authors

a Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland
E-mail: asia@biogeo.uw.edu.pl

b Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland
E-mail: jacekj@biogeo.uw.edu.pl

c College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Poland

d Department of Physics and Biophysics, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

Abstract

7-Methylguanosine (m7G) nucleotides labelled with acetylpyrene (AcPy) were synthesized as fluorescent mRNA 5′ end (cap) analogues. The unique fluorescent properties of m7G–AcPy conjugates, different from G–AcPy, can be applied to studying various mRNA cap-related processes including the evaluation of putative inhibitors of DcpS enzyme—a therapeutic target in neuromuscular diseases.

Graphical abstract: Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

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Article information

DOI
https://doi.org/10.1039/C6OB00419A
Article type
Communication
Submitted
23 Feb 2016
Accepted
08 Mar 2016
First published
08 Mar 2016

Org. Biomol. Chem., 2016,14, 3863-3868

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Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

R. Kasprzyk, J. Kowalska, Z. Wieczorek, M. Szabelski, R. Stolarski and J. Jemielity, Org. Biomol. Chem., 2016, 14, 3863 DOI: 10.1039/C6OB00419A

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