Copper-catalyzed intermolecular amidation of 8-methylquinolines with N-fluoroarylsulfonimides via Csp3–H activation

Xiaolei Zhang; Rui Wu; Wanyi Liu; Dang-Wei Qian; Jinhui Yang; Pengju Jiang; Qing-Zhong Zheng

doi:10.1039/C6OB00553E

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Copper-catalyzed intermolecular amidation of 8-methylquinolines with N-fluoroarylsulfonimides via Csp³–H activation†

Xiaolei Zhang,‡^a Rui Wu,‡^a Wanyi Liu,^a Dang-Wei Qian,^a Jinhui Yang,^a Pengju Jiang^a and Qing-Zhong Zheng*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry and State Key Laboratory Cultivation Base of Natural Gas Conversion, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China
E-mail: qzzheng@nxu.edu.cn

^b State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China

Abstract

An efficient copper-catalyzed C–H amidation of 8-methylquinolines with N-fluoroarylsulfonimides via Csp³–H activation is described. The reaction proceeds with high functional group tolerance, providing a novel approach to valuable quinolin-8-ylmethanamine derivatives in the absence of an additional oxidant.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C6OB00553E
Article type: Communication
Submitted: 14 Mar 2016
Accepted: 30 Apr 2016
First published: 11 May 2016

Download Citation

Org. Biomol. Chem., 2016,14, 4789-4793

Permissions

Request permissions

Copper-catalyzed intermolecular amidation of 8-methylquinolines with N-fluoroarylsulfonimides via Csp³–H activation

X. Zhang, R. Wu, W. Liu, D. Qian, J. Yang, P. Jiang and Q. Zheng, Org. Biomol. Chem., 2016, 14, 4789 DOI: 10.1039/C6OB00553E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry