Issue 27, 2016
From the journal:

Organic & Biomolecular Chemistry

One-pot three-component synthesis of quinazolines via a copper-catalysed oxidative amination reaction†

Tiantian Duan,a   Tianran Zhai,a   Huanhuan Liu,a   Zilong Yan,a   Yue Zhao,a   Lei Fenga  and  Chen Ma*ab  

* Corresponding authors

a Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, P. R. China

b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
E-mail: chenma@sdu.edu.cn

Abstract

A copper-catalysed three-component reaction for constructing a series of quinazoline derivatives has been developed. In this system, solvents act as the reactants and different functional groups are well tolerated to obtain corresponding products in moderate to good yields.

Graphical abstract: One-pot three-component synthesis of quinazolines via a copper-catalysed oxidative amination reaction

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Article information

DOI
https://doi.org/10.1039/C6OB00625F
Article type
Paper
Submitted
23 Mar 2016
Accepted
29 May 2016
First published
31 May 2016

Org. Biomol. Chem., 2016,14, 6561-6567

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One-pot three-component synthesis of quinazolines via a copper-catalysed oxidative amination reaction

T. Duan, T. Zhai, H. Liu, Z. Yan, Y. Zhao, L. Feng and C. Ma, Org. Biomol. Chem., 2016, 14, 6561 DOI: 10.1039/C6OB00625F

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