Issue 20, 2016
From the journal:

Organic & Biomolecular Chemistry

Synthesis of imides via palladium-catalyzed decarboxylative amidation of α-oxocarboxylic acids with secondary amides†

Ning Xu,a   Jie Liu,*ab   Dengke Lia  and  Lei Wang*ac  

* Corresponding authors

a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
E-mail: leiwang@chnu.edu.cn

b Department of Information Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China

c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032, P. R. China

Abstract

An efficient synthesis of imides has been developed through a Pd-catalyzed decarboxylative amidation of α-oxocarboxylic acids with secondary amides. The reactions of N-substituted N-heteroarene-2-carboxamides with 2-oxo-2-arylacetic acids proceeded smoothly to generate the corresponding products in good yields in the presence of Pd(OAc)2 and K2S2O8.

Graphical abstract: Synthesis of imides via palladium-catalyzed decarboxylative amidation of α-oxocarboxylic acids with secondary amides

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Article information

DOI
https://doi.org/10.1039/C6OB00676K
Article type
Paper
Submitted
31 Mar 2016
Accepted
26 Apr 2016
First published
26 Apr 2016

Org. Biomol. Chem., 2016,14, 4749-4757

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Synthesis of imides via palladium-catalyzed decarboxylative amidation of α-oxocarboxylic acids with secondary amides

N. Xu, J. Liu, D. Li and L. Wang, Org. Biomol. Chem., 2016, 14, 4749 DOI: 10.1039/C6OB00676K

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