Issue 28, 2016
From the journal:

Organic & Biomolecular Chemistry

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus†

Matthew D. Stephens,a   Nisakorn Yodsanitb  and  Christian Melander*a  

* Corresponding authors

a Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA
E-mail: ccmeland@ncsu.edu

b Department of Chemistry, Mahidol University, Bangkok, Thailand 10400

Abstract

A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N-(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50 values.

Graphical abstract: Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6OB00706F
Article type
Paper
Submitted
04 Apr 2016
Accepted
14 Jun 2016
First published
16 Jun 2016

Org. Biomol. Chem., 2016,14, 6853-6856

Permissions

Request permissions

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

M. D. Stephens, N. Yodsanit and C. Melander, Org. Biomol. Chem., 2016, 14, 6853 DOI: 10.1039/C6OB00706F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements