Issue 20, 2016
From the journal:

Organic & Biomolecular Chemistry

Trifluoroacetic acid catalyzed highly regioselective bromocyclization of styrene-type carboxylic acid†

Tao Chena  and  Ying-Yeung Yeung*ab  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore

b Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
E-mail: yyyeung@cuhk.edu.hk

Abstract

A trifluoroacetic acid catalyzed highly 6-endo regioselective bromocyclization of styrene-type carboxylic acid has been developed. The resulting 3,4-dihydroisocoumarines are valuable building blocks in organic synthesis.

Graphical abstract: Trifluoroacetic acid catalyzed highly regioselective bromocyclization of styrene-type carboxylic acid

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Article information

DOI
https://doi.org/10.1039/C6OB00756B
Article type
Communication
Submitted
09 Apr 2016
Accepted
22 Apr 2016
First published
25 Apr 2016

Org. Biomol. Chem., 2016,14, 4571-4575

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Trifluoroacetic acid catalyzed highly regioselective bromocyclization of styrene-type carboxylic acid

T. Chen and Y. Yeung, Org. Biomol. Chem., 2016, 14, 4571 DOI: 10.1039/C6OB00756B

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