Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

John D. Sidda; Vincent Poon; Lijiang Song; Weishan Wang; Keqian Yang; Christophe Corre

doi:10.1039/C6OB00840B

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Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152†

John D. Sidda,^a Vincent Poon,^a Lijiang Song,^a Weishan Wang,^b Keqian Yang^b and Christophe Corre

*^a

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* Corresponding authors

^a Department of Chemistry and School of Life Sciences, University of Warwick, Coventry, UK
E-mail: C.Corre@warwick.ac.uk
Fax: +44 (0)2476 524 112
Tel: +44 (0)2476 523 557

^b State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, No. 1 West Beichen Road, Chaoyang District, Beijing 100101, People's Republic of China

Abstract

Gamma-butyrolactones (GBLs) are signalling molecules that control antibiotic production in Streptomyces bacteria. The genetically engineered strain S. coelicolor M1152 was found to overproduce GBLs SCB1–3 as well as five novel GBLs named SCB4–8. Incorporation experiments using isotopically-labelled precursors confirmed the chemical structures of SCB1–3 and established those of SCB4–8.

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DOI: https://doi.org/10.1039/C6OB00840B
Article type: Communication
Submitted: 19 Apr 2016
Accepted: 10 May 2016
First published: 10 May 2016
This article is Open Access

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Org. Biomol. Chem., 2016,14, 6390-6393

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Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

J. D. Sidda, V. Poon, L. Song, W. Wang, K. Yang and C. Corre, Org. Biomol. Chem., 2016, 14, 6390 DOI: 10.1039/C6OB00840B

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Organic & Biomolecular Chemistry

Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152†

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Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

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