Issue 26, 2016

Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals

Abstract

A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.

Graphical abstract: Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2016
Accepted
16 May 2016
First published
17 May 2016

Org. Biomol. Chem., 2016,14, 6193-6196

Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals

D. Zhou, X. Yu, J. Zhang, W. Wang and H. Xie, Org. Biomol. Chem., 2016, 14, 6193 DOI: 10.1039/C6OB00890A

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