Issue 23, 2016

Base-catalyzed controllable reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates for the synthesis of amidoacrylates and spiroaziridine oxindoles

Abstract

A base-catalyzed divergent reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates has been developed to provide efficient access to various amidoacrylates and spiroaziridine oxindoles with generally high yields, which should be potentially useful in drug discovery.

Graphical abstract: Base-catalyzed controllable reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates for the synthesis of amidoacrylates and spiroaziridine oxindoles

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2016
Accepted
16 May 2016
First published
17 May 2016

Org. Biomol. Chem., 2016,14, 5224-5228

Base-catalyzed controllable reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates for the synthesis of amidoacrylates and spiroaziridine oxindoles

Y. Liu, S. Duan, R. Zhang, Y. Liu, J. Chen and W. Xiao, Org. Biomol. Chem., 2016, 14, 5224 DOI: 10.1039/C6OB00891G

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