Synthesis of isoquinolines via Rh-catalyzed C–H activation/C–N cyclization with diazodiesters or diazoketoesters as a C2 source

Abstract

Synthesis of isoquinolines based on efficient C–C and C–N bond formation through Rh(III)-catalyzed C–H activation and subsequent intramolecular cyclization is reported. Diazodiesters serving as a C₂ source in the newly formed heterocycles are first demonstrated. Additionally, the Rh(III)-catalyzed direct C–H activation/cyclization of benzimidates with diazoketoesters is also described.