Issue 28, 2016

Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

Abstract

An efficient approach for the synthesis of Z-1,3-enynes based on the coupling reaction of Z-vinyl tellurides and alkynes containing a pseudoglycoside moiety is described. The products were obtained in good yields via a stereoselective way. Preliminary screening against three tumor cell lines indicated that the synthesized compounds are promising intermediates for the synthesis of an array of more potent target structures.

Graphical abstract: Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

Supplementary files

Article information

Article type
Paper
Submitted
30 Apr 2016
Accepted
08 Jun 2016
First published
08 Jun 2016

Org. Biomol. Chem., 2016,14, 6786-6794

Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

C. R. Dantas, J. J. R. de Freitas, Q. P. S. Barbosa, G. C. G. Militão, T. D. S. Silva, T. G. da Silva, A. A. S. Paulino, J. C. R. Freitas, R. A. Oliveira and P. H. Menezes, Org. Biomol. Chem., 2016, 14, 6786 DOI: 10.1039/C6OB00945J

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