Issue 26, 2016

UGT74B1 from Arabidopsis thaliana as a versatile biocatalyst for the synthesis of desulfoglycosinolates

Abstract

Thioglycosides, even if rare in Nature, have gained increased interest for their biological properties. Chemical syntheses of this class of compounds have been largely studied but little has been reported on their biosynthesis. Herein, combining experiments from the different fields of enzymology, bioorganic chemistry and molecular modeling, we wish to demonstrate the versatility of the glucosyltransferase UGT74B1 and its synthetic potency for the preparation of a variety of natural and unnatural desulfoglycosinolates.

Graphical abstract: UGT74B1 from Arabidopsis thaliana as a versatile biocatalyst for the synthesis of desulfoglycosinolates

Supplementary files

Article information

Article type
Paper
Submitted
08 May 2016
Accepted
24 May 2016
First published
25 May 2016

Org. Biomol. Chem., 2016,14, 6252-6261

UGT74B1 from Arabidopsis thaliana as a versatile biocatalyst for the synthesis of desulfoglycosinolates

S. Marroun, S. Montaut, S. Marquès, P. Lafite, G. Coadou, P. Rollin, G. Jousset, M. Schuler, A. Tatibouët, H. Oulyadi and R. Daniellou, Org. Biomol. Chem., 2016, 14, 6252 DOI: 10.1039/C6OB01003B

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