Issue 31, 2016

A rare γ-pyranopyrazole skeleton: design, one-pot synthesis and computational study

Abstract

Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straightforward synthetic route has been developed for a range of pyrazole fused γ-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of γ-pyranopyrazole is furthermore fully supported by experimental and computational studies.

Graphical abstract: A rare γ-pyranopyrazole skeleton: design, one-pot synthesis and computational study

Supplementary files

Article information

Article type
Paper
Submitted
19 May 2016
Accepted
05 Jul 2016
First published
05 Jul 2016
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2016,14, 7490-7494

A rare γ-pyranopyrazole skeleton: design, one-pot synthesis and computational study

M. Üçüncü, C. Cantürk, E. Karakuş, H. Zeybek, U. Bozkaya, E. Soydaş, E. Şahin and M. Emrullahoğlu, Org. Biomol. Chem., 2016, 14, 7490 DOI: 10.1039/C6OB01099G

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