A facile and general procedure for the preparation of alkynyl C-nucleosides with varied fluorophores is presented. Sonogashira coupling was used as a key reaction to conjugate the dyes to an easily accessible ethynyl functionalized deoxyribose derivative. The new C-nucleosides were used for the preparation of DNA-based polyfluorophores.
D. K. Kölmel, L. J. Barandun and E. T. Kool, Org. Biomol. Chem., 2016, 14, 6407 DOI: 10.1039/C6OB01199C
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