Issue 29, 2016
From the journal:

Organic & Biomolecular Chemistry

Synthesis of sulfonamides via copper-catalyzed oxidative C–N bond cleavage of tertiary amines†

Jing Ji,‡a   Zhengyi Liu,‡a   Ping Liua  and  Peipei Sun*a  

* Corresponding authors

a College of Chemistry and Materials Science, Nanjing Normal University; Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing 210023, China
E-mail: sunpeipei@njnu.edu.cn

Abstract

A copper-catalyzed coupling reaction of sulfonyl chlorides with tertiary amines via the oxidative C–N bond cleavage of tertiary amines was developed. Sulfonamides were synthesized using this strategy in moderate to good yields. The reaction was applicable to various tertiary amines, as well as sulfonyl chlorides.

Graphical abstract: Synthesis of sulfonamides via copper-catalyzed oxidative C–N bond cleavage of tertiary amines

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Article information

DOI
https://doi.org/10.1039/C6OB01208F
Article type
Paper
Submitted
03 Jun 2016
Accepted
23 Jun 2016
First published
24 Jun 2016

Org. Biomol. Chem., 2016,14, 7018-7023

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Synthesis of sulfonamides via copper-catalyzed oxidative C–N bond cleavage of tertiary amines

J. Ji, Z. Liu, P. Liu and P. Sun, Org. Biomol. Chem., 2016, 14, 7018 DOI: 10.1039/C6OB01208F

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