Issue 31, 2016

Nickel catalyzed α-arylation of ketones with aryltrimethylammonium triflates

Abstract

Nickel-catalyzed α-arylation of ketones involving aromatic C–N cleavage has been accomplished. Intermolecular coupling of aromatic ketones with a variety of aryltrimethylammonium triflates was achieved in the presence of Ni(COD)2, IPr·HCl, and LiOBut, giving α-arylated ketones in reasonable to excellent yields.

Graphical abstract: Nickel catalyzed α-arylation of ketones with aryltrimethylammonium triflates

Supplementary files

Article information

Article type
Paper
Submitted
16 Jun 2016
Accepted
18 Jul 2016
First published
18 Jul 2016

Org. Biomol. Chem., 2016,14, 7579-7584

Nickel catalyzed α-arylation of ketones with aryltrimethylammonium triflates

J. Li and Z. Wang, Org. Biomol. Chem., 2016, 14, 7579 DOI: 10.1039/C6OB01299J

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