Issue 46, 2016

Progress in aminosugar derived asymmetric organocatalysis

Abstract

In the last decade aminosugars, especially D-glucoamine based organocatalysts, have been applied to catalyze various asymmetric reactions such as aldol reactions, Michael addition, Strecker reactions, Biginelli reactions, epoxidation, fluorination, and imine reduction, and for the synthesis of various biologically important molecules such as 3-alkylnitro-2-hydroxynaphthoquinones, trans-dihydrobenzofurans etc. Immense growth has been also observed in the structural modification of aminosugar based organocatalysts to obtain the best results from them. This review sheds light on such organocatalytic transformations reported in last the decade including the effect of the structural modification of sugar amines on their catalytic efficiency and the stereoselectivity of the reaction.

Graphical abstract: Progress in aminosugar derived asymmetric organocatalysis

Article information

Article type
Review Article
Submitted
09 Jul 2016
Accepted
12 Oct 2016
First published
12 Oct 2016

Org. Biomol. Chem., 2016,14, 10747-10762

Progress in aminosugar derived asymmetric organocatalysis

J. Agarwal, Org. Biomol. Chem., 2016, 14, 10747 DOI: 10.1039/C6OB01462C

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