Issue 46, 2016
From the journal:

Organic & Biomolecular Chemistry

A new synthesis and preliminary evaluation of some analogues of mecamylamine – a compound with anti-addiction properties†

David Mangan,a   Neasa McNabola,a   Emily H. Clark,b   Isabel Bermudez,c   Susan Wonnacottb  and  J. Mike Southern*a  

* Corresponding authors

a Trinity Biomedical Sciences Institute, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland
E-mail: southerj@tcd.ie

b Department of Biology & Biochemistry, University of Bath, Bath BA2 7AY, UK

c School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK

Abstract

A new synthesis of mecamylamine – a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.

Graphical abstract: A new synthesis and preliminary evaluation of some analogues of mecamylamine – a compound with anti-addiction properties

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Article information

DOI
https://doi.org/10.1039/C6OB01974A
Article type
Communication
Submitted
07 Sep 2016
Accepted
25 Oct 2016
First published
25 Oct 2016

Org. Biomol. Chem., 2016,14, 10787-10798

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A new synthesis and preliminary evaluation of some analogues of mecamylamine – a compound with anti-addiction properties

D. Mangan, N. McNabola, E. H. Clark, I. Bermudez, S. Wonnacott and J. M. Southern, Org. Biomol. Chem., 2016, 14, 10787 DOI: 10.1039/C6OB01974A

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