Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

H. Park; S. Walta; R. R. Rosencrantz; A. Körner; C. Schulte; L. Elling; W. Richtering; A. Böker

doi:10.1039/C5PY00797F

Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding†

H. Park,‡^a S. Walta,‡^b R. R. Rosencrantz,‡^c A. Körner,^a C. Schulte,^d L. Elling,*^c W. Richtering

*^b and A. Böker §*^a

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* Corresponding authors

^a DWI – Leibniz Institut für Interaktive Materialien e.V., Lehrstuhl für Makromolekulare Materialien und Oberflächen, Forckenbeckstr. 50, Aachen, Germany

^b Institute of Physical Chemistry, RWTH Aachen University, JARA – Soft Matter Science, Landoltweg 2, D-52074 Aachen, Germany
E-mail: wrichtering@pc.rwth-aachen.de

^c Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074 Aachen, Germany
E-mail: l.elling@biotec.rwth-aachen.de

^d Fraunhofer-Institut für Angewandte Polymerforschung, Lehrstuhl für Polymermaterialien und Polymertechnologie, Universität Potsdam, Geiselbergstraße 69, 14476 Potsdam-Golm, Germany

Abstract

We introduce a novel double-hydrophilic hydroxyethylmethacrylate (HEMA) based diblock glycopolymer which self-assembles into homogeneous spherical micellar structures in water. The micellar structure renders surface-oriented N-acetylglucocosamine (GlcNAc) sugar moieties for strong multivalent glycan-mediated lectin binding. Structural analysis and lectin binding is performed by microscopy methods, dynamic light scattering (DLS) and two-focus fluorescence correlation spectroscopy (2fFCS), revealing a novel micellar type of multivalent sugar binding scaffold with high potential for biomedical applications.

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DOI: https://doi.org/10.1039/C5PY00797F
Article type: Paper
Submitted: 26 May 2015
Accepted: 30 Nov 2015
First published: 02 Dec 2015

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Polym. Chem., 2016,7, 878-886

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Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

H. Park, S. Walta, R. R. Rosencrantz, A. Körner, C. Schulte, L. Elling, W. Richtering and A. Böker, Polym. Chem., 2016, 7, 878 DOI: 10.1039/C5PY00797F

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Polymer Chemistry

Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding†

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Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

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