Phosgene-free synthesis of non-ionic hydrophilic polyserine†
Abstract
Non-ionic water-soluble poly-DL-serine (PSer) was synthesized from an activated urethane-type derivative of serine. SEC, NMR and MALDI-ToF analyses of the polypeptides revealed a controllable polymerization initiated by primary or secondary amines. PSer exhibited excellent solubility in water when the ratios of L-serine/D-serine units ranged from 5/5 to 8/2.