A water-soluble conjugated polymer with azobenzol side chains based on “turn-on” effect for hypoxic cell imaging

Jie Li; Yan Yuan; Gaoshan Zeng; Xiang Li; Zhen Yang; Xiaozhen Li; Rongcui Jiang; Wenbo Hu; Pengfei Sun; Qi Wang; Xiaomei Lu; Quli Fan; Wei Huang

doi:10.1039/C6PY01567K

A water-soluble conjugated polymer with azobenzol side chains based on “turn-on” effect for hypoxic cell imaging†

Jie Li,^a Yan Yuan,^b Gaoshan Zeng,^a Xiang Li,^a Zhen Yang,^a Xiaozhen Li,^a Rongcui Jiang,^a Wenbo Hu,^a Pengfei Sun,^a Qi Wang,^a Xiaomei Lu,^b Quli Fan*^a and Wei Huang*^ab

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* Corresponding authors

^a Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
E-mail: iamqlfan@njupt.edu.cn
Fax: +86 25 8586 6533
Tel: +86 25 8586 6396

^b Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China
E-mail: wei-huang@njtech.edu.cn
Fax: +86 25 5813 9988
Tel: +86 25 5813 9001

Abstract

A water-soluble conjugated polymer (WSCP) with enzymatic cleavable linkages (azobenzene) side chains for hypoxia imaging is reported. The fluorescence of the polymer would be recovered as the azobenzene moieties cleaved in hypoxia. This conjugated polymer was proved to be a good hypoxic sensor.

Polymer Chemistry

A water-soluble conjugated polymer with azobenzol side chains based on “turn-on” effect for hypoxic cell imaging†

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A water-soluble conjugated polymer with azobenzol side chains based on “turn-on” effect for hypoxic cell imaging

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