Issue 2, 2016

Non-covalent organocatalysis in asymmetric oxidative C(sp3)–H bond functionalization – broadening C–H bond coupling reactions

Abstract

Among the current huge development activities in C–H functionalization, asymmetric oxidative C(sp3)–H bond coupling strategies have remained underrepresented. Beyond the initial examples using chiral metal complexes, the use of organocatalysis provides a new direction for the design of new asymmetric C–H bond cross-coupling reactions. This highlight focuses on the latest advances in metal-free asymmetric oxidative C(sp3)–H bond functionalization using cooperative non-covalent organocatalysis.

Graphical abstract: Non-covalent organocatalysis in asymmetric oxidative C(sp3)–H bond functionalization – broadening C–H bond coupling reactions

Article information

Article type
Highlight
Submitted
04 Nov 2015
Accepted
06 Dec 2015
First published
08 Dec 2015
This article is Open Access
Creative Commons BY license

Org. Chem. Front., 2016,3, 277-280

Non-covalent organocatalysis in asymmetric oxidative C(sp3)–H bond functionalization – broadening C–H bond coupling reactions

S. Stockerl and O. G. Mancheño, Org. Chem. Front., 2016, 3, 277 DOI: 10.1039/C5QO00347D

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