Issue 10, 2016

Ru-Catalyzed selective C–H oxidative olefination with N-heteroarenes directed by pivaloyl amide

Abstract

A highly efficient and practical Ru-catalyzed direct C–H functionalization of indolines and N-alkylaniline with a simple pivaloyl as a directing group is developed. Broad substrate scopes with respect to N-heteroarenes and olefins are observed. The selective C7-position alkynylation for indoline also proceeds well by using inexpensive ruthenium as a catalyst, and pivaloyl as a directing group.

Graphical abstract: Ru-Catalyzed selective C–H oxidative olefination with N-heteroarenes directed by pivaloyl amide

Supplementary files

Article information

Article type
Research Article
Submitted
04 Jul 2016
Accepted
07 Aug 2016
First published
08 Aug 2016

Org. Chem. Front., 2016,3, 1271-1275

Ru-Catalyzed selective C–H oxidative olefination with N-heteroarenes directed by pivaloyl amide

L. Zhang, C. Chen, J. Han, Z. Huang and Y. Zhao, Org. Chem. Front., 2016, 3, 1271 DOI: 10.1039/C6QO00327C

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