A highly efficient one-pot trifluoromethylation/cyclization reaction of electron-deficient 1,3-conjugated enynes: modular access to trifluoromethylated furans and 2,3-dihydrofurans

Abstract

A highly efficient one-pot trifluoromethylation/cyclization reaction of conjugated enyne aldehydes and ketones was developed, which provides modular access to highly substituted trifluoromethylated furans and 2,3-dihydrofurans. This method has the advantages of mild reaction conditions, wide functional group tolerance, high yields and being transition metal free.