Synthesis of spiro[indane-1,3-dione-1-pyrrolines] via copper-catalyzed heteroannulation of ketoxime acetates with 2-arylideneindane-1,3-diones

Abstract

A cuprous cyanide-catalyzed heteroannulation reaction of 2-arylideneindane-1,3-dione with ketoxime acetates has been developed for the synthesis of novel spiro[indane-1,3-dione-1-pyrrolines] through the cleavage of N–O and C–H bonds and formation of C–C and C–N bonds. The synthetic strategy shows broad substrate scope and furnishes spiro[indane-1,3-dione-1-pyrrolines] in high yields.