Issue 11, 2016

Biodegradable polyurethane acrylate/HEMA-grafted nanodiamond composites with bone regenerative potential applications: structure, mechanical properties and biocompatibility

Abstract

The present study demonstrates HEMA-grafted nanodiamond (ND-HEMA)/acrylate-terminated polyurethane-acrylate diluents (APUA) composites as promising materials for bone implant applications. Neat APUA and APUA composites containing ND-HEMA at different loadings up to 2 wt% were prepared by an in situ polymerization method. Morphological analysis demonstrated that ND-HEMAs were actually in the form of tightly bound aggregates which led to formation of big agglomerates at a concentration of 2 wt%. It was also suggested that ND-HEMAs were preferentially localized in the continuous soft domain of APUA; however it interacted by both soft and hard domains. Moreover, ND-HEMAs caused considerable phase separation between soft and hard domains as well as increased crystallinity. Maximum improvement in tensile properties of APUA was observed at 1 wt% loading of ND-HEAMs, namely 175% improvement in modulus and 40% increase in strength. The hydrophilic nature of ND-HEMA enhanced water absorption of composites resulted in higher hydrolysis degradation of APUA. In vitro biocompatibility evaluation via culturing human osteosarcoma cells (MG-63 osteoblast-like cell line), demonstrated no adverse effect on the cell viability of samples. Furthermore, the composites showed favorable cell adhesion and growth, and ND-HEMAs did not cause any negative effect on proliferation, ALP production and osteoblast attachment by MG-63 cells compared with neat APUA.

Graphical abstract: Biodegradable polyurethane acrylate/HEMA-grafted nanodiamond composites with bone regenerative potential applications: structure, mechanical properties and biocompatibility

Article information

Article type
Paper
Submitted
23 Sep 2015
Accepted
04 Jan 2016
First published
08 Jan 2016

RSC Adv., 2016,6, 8743-8755

Author version available

Biodegradable polyurethane acrylate/HEMA-grafted nanodiamond composites with bone regenerative potential applications: structure, mechanical properties and biocompatibility

M. Alishiri, A. Shojaei and M. J. Abdekhodaie, RSC Adv., 2016, 6, 8743 DOI: 10.1039/C5RA19669H

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